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| Boilerpipe Text | Dr Joshua Hyong-Jin Cho, Dr Paul Barkopoulos, and Dr Anthony E. Reading would like to gratefully acknowledge Dr John W. Winkelman, Dr Teofilo Lee-Chiong, and Dr Vipin Malik, previous contributors to this topic. Disclosures JWW has received honoraria for consulting to Avadel, CVS, Eisai, and Merck, and research grants from Merck and the RLS Foundation. TLC is the Chief Medical Liaison for Philips, a company that makes devices to treat sleep apnoea. VM received research funding from Philips Respironics for a study on COPD-OSA overlap. |
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# Insomnia
[View PDF](https://bestpractice.bmj.com/topics/en-gb/227/pdf/227/Insomnia.pdf)
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- Overview 
- Theory 
- Diagnosis 
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- [Overview](https://bestpractice.bmj.com/topics/en-gb/227)
- [Summary](https://bestpractice.bmj.com/topics/en-gb/227)
- [Theory](https://bestpractice.bmj.com/topics/en-gb/227)
- Epidemiology
- Aetiology
- Case history
- [Diagnosis](https://bestpractice.bmj.com/topics/en-gb/227)
- Approach
- History and exam
- Investigations
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- Approach
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Last reviewed: 13 Nov 2025
Last updated: 21 Oct 2025
## Summary
Insomnia is one of the most common complaints reported in primary care.
Diagnosis is made primarily by patient interview. Sleep diaries, actigraphy, and polysomnography may assist in confirming diagnosis.
Identification of the correct aetiology, contributing factors, and/or comorbidities is essential for adequate treatment of insomnia. Their management is necessary, although often not sufficient, for the resolution of insomnia.
The significant morbidity of insomnia indicates that it is a condition that warrants treatment.
Take an individualised approach to treatment, based on the patient's preferences, the severity of their insomnia, the risks versus benefits of treatment, and the availability of specialist treatment options such as cognitive behavioural therapy.
For most patients, initial treatment with cognitive behavioural therapy for insomnia (CBT-I) is likely to provide the best balance between efficacy and safety.
### Definition
The Diagnostic and Statistical Manual of Mental Disorders, 5th edition, Text Revision (DSM-5-TR) defines insomnia disorder (i.e., clinical insomnia) as difficulty initiating sleep, difficulty maintaining sleep, or early-morning awakening despite adequate opportunity for sleep; leading to clinically significant distress or impairments in functioning; and with a frequency of 3 or more nights per week and a duration of 3 months or longer.[\[1\]](https://bestpractice.bmj.com/topics/en-gb/227#referencePop1)American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed., text revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022. https://www.psychiatry.org/psychiatrists/practice/dsm Insomnia is not explained by the presence of mental disorders or medical conditions and is not associated with another sleep-wake disorder.
### History and exam
#### Key diagnostic factors
- presence of risk factors
- sleep partner complaints
- delayed sleep onset
- multiple or long awakenings
Full details
#### Other diagnostic factors
- impairment of functioning
- accidents
- decreased sleep time
- daytime napping
- thyrotoxicosis
- chronic pain
- restless legs syndrome
- obstructive sleep apnoea
Full details
#### Risk factors
- female sex
- advanced age
- chronic medical conditions
- chronic pain
- psychiatric illness
- alcohol or substance misuse
- stimulant use
- poor sleep hygiene
- traumatic brain injury
- neuropsychiatric illness
- use of certain medications
- recent travel across time zones
- night work
- hyperthyroidism
- participation in elite sport
- sedentary behaviour
Full details
[Log in or subscribe to access all of BMJ Best Practice](https://bestpractice.bmj.com/log-in)
### Diagnostic investigations
#### 1st investigations to order
- sleep diary
- Pittsburgh Sleep Quality Index (PSQI)
- Insomnia Severity Index (ISI)
- Stanford Sleepiness Scale (SSS)
- Epworth Sleepiness Scale (ESS)
- Athens Insomnia Scale (AIS)
- Generalised Anxiety Disorder-7 (GAD-7)
- Patient Health Questionnaire-9 (PHQ-9)
Full details
#### Investigations to consider
- polysomnography (PSG)
- actigraphy
- thyroid-stimulating hormone (TSH)
- FBC and iron studies
- urine or blood substance use panel
Full details
[Log in or subscribe to access all of BMJ Best Practice](https://bestpractice.bmj.com/log-in)
### Treatment algorithm
ACUTE
### acute insomnia
ONGOING
### chronic insomnia
[Log in or subscribe to access all of BMJ Best Practice](https://bestpractice.bmj.com/log-in)
### Contributors
VIEW ALLAuthors
#### Authors
##### Joshua Hyong-Jin Cho, MD, PhD
Health Sciences Clinical Professor
Director, UCLA Insomnia Clinic
Cousins Center for Psychoneuroimmunology
Department of Psychiatry & Biobehavioral Sciences
David Geffen School of Medicine at UCLA
Los Angeles
CA
###### Disclosures
JHC is an author of a reference cited in this topic.
##### Paul Barkopoulos, MD, MPH
Clinical Professor
Department of Psychiatry & Biobehavioral Sciences
David Geffen School of Medicine at UCLA
Los Angeles
CA
###### Disclosures
PB is an author of a reference cited in this topic.
##### Anthony E. Reading, MPhil, PhD
Clinical Professor
Department of Psychiatry & Biobehavioral Sciences
David Geffen School of Medicine at UCLA
Los Angeles
CA
###### Disclosures
AER declares that he has no competing interests.
##### Acknowledgements
Dr Joshua Hyong-Jin Cho, Dr Paul Barkopoulos, and Dr Anthony E. Reading would like to gratefully acknowledge Dr John W. Winkelman, Dr Teofilo Lee-Chiong, and Dr Vipin Malik, previous contributors to this topic.
###### Disclosures
JWW has received honoraria for consulting to Avadel, CVS, Eisai, and Merck, and research grants from Merck and the RLS Foundation. TLC is the Chief Medical Liaison for Philips, a company that makes devices to treat sleep apnoea. VM received research funding from Philips Respironics for a study on COPD-OSA overlap.
VIEW ALLPeer reviewers
#### Peer reviewers
##### Karl Doghramji, MD
Director
Sleep Disorders Center
Thomas Jefferson University Hospital
Philadelphia
PA
###### Disclosures
KD is a speaker for Sanofi-Aventis, King Pharmaceuticals, Takeda Pharmaceuticals, Sepracor, and Pfizer; a consultant for Sanofi-Aventis, Takeda Pharmaceuticals, Sepracor, Pfizer, and Neurocrine Biosciences; and has stock in Merck.
##### Chiadi U. Onyike, MD, MHS
Assistant Professor
Geriatric Psychiatry and Neuropsychiatry
The Johns Hopkins Hospital
Baltimore
MD
###### Disclosures
CUO declares that he has no competing interests.
##### Roy Goldberg, MD
Medical Director
Kings Harbor Multicare Center
Bronx
NY
###### Disclosures
RG declares that he has no competing interests.
##### Craig Sawchuk, MD
Affiliate Assistant Professor
Department of Psychiatry and Behavioral Sciences
University of Washington Medical Center
Seattle
WA
###### Disclosures
CS declares that he has no competing interests.
##### David Cunnington, MD
Director
Melbourne Sleep Disorders Centre
Melbourne
Victoria
Australia
###### Disclosures
DC has received consulting fees from Sanofi-Aventis and Lundbeck, and honoraria for speaking from Sanofi-Aventis.
##### Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
###### Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
### References
*Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.*
#### Key articles
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed., text revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.[Full text](https://www.psychiatry.org/psychiatrists/practice/dsm)
Sateia MJ, Buysse DJ, Krystal AD, et al. Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2017 Feb 15;13(2):307-49.[Full text](https://jcsm.aasm.org/doi/10.5664/jcsm.6470) [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/27998379?tool=bestpractice.com)
Qaseem A, Kansagara D, Forciea MA, et al. Management of chronic insomnia disorder in adults: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2016 Jul 19;165(2):125-33.[Full text](https://www.acpjournals.org/doi/10.7326/M15-2175) [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/27136449?tool=bestpractice.com)
Edinger JD, Arnedt JT, Bertisch SM, et al. Behavioral and psychological treatments for chronic insomnia disorder in adults: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2021 Feb 1;17(2):255-62.[Full text](https://jcsm.aasm.org/doi/10.5664/jcsm.8986) [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/33164742?tool=bestpractice.com)
#### Reference articles
##### A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
- #### Differentials
- Restless legs syndrome
- Periodic limb movement disorder (PLMD)
- Obstructive sleep apnoea (OSA)
More Differentials
- #### Guidelines
- Australasian Sleep Association 2024 guidelines for sleep studies in adults
- Manual for the scoring of sleep and associated events
More Guidelines
- #### Patient information
Insomnia
Sleep apnoea in adults (obstructive)
More Patient information
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